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Besides dopamine, smoking also activates the release of other molecules in the brain that make you feel good, including chemicals called endogenous opioids, according to 2004 research from the University of Michigan.
“Only five percent of unaided quit attempts result in successful abstinence,” McClernon said. “Quitting smoking dramatically increases brain activity in response to seeing smoking cues, which seems to indicate that quitting smoking is actually sensitizing the brain to these smoking cues,” thus explaining why most smokers who try to quit tend to relapse.
“If we’re really going to help people quit, this emphasizes the need to do more than tell people to resist temptation. We also have to help them break that habitual response,” McClernon said.
The study is detailed online in the journal Psychopharmacology. Further research is focusing on the use of a nicotine patch prior to quitting smoking to break the mental link between cigarettes and nicotine.
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