Natural Liver Cleansing Product L-Citrulline Article

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Natural Liver Cleansing Product L-Citrulline

Patients with rheumatoid arthritis often (at least 80% of them) develop an immune response against proteins containing L-Citrulline.

Author: Homeherb

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The liver is involved in thousands of biochemical mechanisms making it second only to the brain in importance and complexity. Natural health practitioners are also acutely aware of the detrimental effects on the liver of modern living, with its chemicals, excessive fat intake, pesticides, hormones, and stress. This suggests that we as a culture are in need of liver support. You should consider liver support supplementation if you:

• Have a history of a Fatty Liver
• Consume Alcohol
• Consume Tobacco Products
• Have been taking Medications/Drugs
• Are exposed to Environmental Toxins or Chemicals or Second Hand Smoke
• Have a history of Liver or Gall Bladder Problems

L-Citrulline:
The chemical compound L-Citrulline is an α-amino acid (AA). Its name is derived from citrullus, the Latin word for watermelon, from which it was first isolated.

L-Citrulline Made From:
L-Citrulline is made from ornithine and carbamoyl phosphate in one of the central reactions in the urea cycle. It is also produced from arginine as a by-product of the reaction catalyzed by NOS family. First arginine is oxidized into N-hydroxyl-arginine, which is then further oxidized to L-Citrulline concomitant with release of nitric oxide.

How L-Citrulline Works?
L-Citrulline, while being an amino acid, is not built into proteins during protein synthesis, as it is not coded for by DNA, yet several proteins are known to contain L-Citrulline. These L-Citrulline residues are generated by a family of enzymes called peptidylarginine deiminases (PADs), which convert Arginine into L-Citrulline in a process called citrullination or deimination. Proteins that normally contain L-Citrulline residues include myelin basic protein (MBP), filaggrin and several histone proteins, while other proteins, like fibrin and vimentin can get citrullinated during cell death and tissue inflammation.

Patients with rheumatoid arthritis often (at least 80% of them) develop an immune response against proteins containing L-Citrulline. Although the origin of this immune response is not known, detection of antibodies reactive with L-Citrulline containing proteins or peptides is now becoming an important help in the diagnosis of rheumatoid arthritis.

More about L-Citrulline:
L-Citrulline, like L-arginine and L-ornithine, is a metabolite in the urea cycle and is involved in liver detoxification and vasodilation pathways. It is produced in the urea cycle when carbamoyl phosphate is converted to L-Citrulline in the ornithine carbamoyltransferase reaction. When endogenous supplies of ornithine carbamoyltransferase are insufficient, supplementation L-Citrulline has been shown to support ammonia incorporation and liver detoxification of ammonia. Free form amino acid, high purity, well tolerated. For additional support, one may include Item no. 50740 Magnesium Malate Forte.

L-Citrulline Suggested Use:
As a dietary supplement, 1 and 1/4 teaspoons two times daily, or as directed by a healthcare practitioner. Contraindicated for individuals with kidney abnormalities, a hypersensitivity to L-L-Citrulline and for children under 12 years of age.

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